Initial Stroke Analysis

Introduction

The International Stroke Trial v. 2 data

• Assessing efficacy and safety of antithrombotic therapy compared to control.
• Antithrombotic agents: Aspirin and subcutaneous Heparin.

Ischaemic stroke and treatments

• Ischaemic stroke: Medical condition in which poor blood flow to a part of the brain causes cell death

Project Aim

• Assessing effects of antithrombotics (heparin and aspirin) for recurrent ischaemic strokes

Methods

Raw data:

• 19435 observations with 112 variables.

01_load:

• Data has been loaded and saved in a tsv-file.

02_clean:

• Global syntax of NA, and Y/N for binary variables.
• Global syntax for the use of numbers 1-8 as to describe causes of death.
• Correction of errors made when the data was collected.
• Removal of column determined to be irrelevant.
• Merging of columns for easier data analysis.
• Data was split and re-joined into one.

03_augment

• Groups created based on different treatments, and different doses of aspirin and heparin.

Descriptive analysis

[1] "Missing treatment group image"

Impact of treatment on subgroups

Models of the bla bla

Time of death after randomization

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Events during first 14 days

Data visualization:

Kaplan Meier Plot after stroke:

Chi squared test of the treatment effect